Apotil Oral SOl. (tilmicOSIn phosphate) is a semi-synthetically produced long-acting broad spectrum macrolide antibiotic with particular pulmonic empathy. Apotil Oral Sol. concentrates in the lungs &penetrates intracellularly in the alveolar macrophages. Apotil Oral Sol. has significant activity against Gram positive & certain Gram negative bacteria & Mycoplasmas. Indications: Poultry: Prophylactics and treatment of bacterial respiratory diseases caused by Mycoplasma gallisepticum, MIyCoplasma synoviae, Ornithobacterium rhinotracheale (ORT), Pasteurella multocida (fowl cholera) and other microorganisms sensitive to tilmicosin. Calves: Bovine respiratory syndrome associated with Pasteurealla multocida and Mannheimia haemolytica. treatment of interdigital necrobacillosis