All infectious diseases caused by gram-positive and gram-negative bacteria in all species of animals, but especially enteritis, septicemia, salmonellosis, pasteurellosis, coliinfections, metritis, peritonitis and pneumonia. Kanamycin is an antibiotic with strong activity against mainly gram-negative bacteria and some gram-positive bacteria. Also staphylococci producing penicillinase are susceptible to kanamycin. Neomycin has a broad-spectrum antibiotic, is especially active against both gram-positive and gram-negative bacteria. Colistin, a restricted spectrum antibiotic, is especially active against gram-negative bacteria like E. coli, but moreover Salmonella sp. (S. dublin, S. typhymurium, etc.) Dexamethasone, a synthetic glucocorticosteroid, diminishes the inflammatory and phlogistic reactions caused by the infectious agents in the tissues, Its antiphlogistic action facilitates the diffusion of the antibiotics into the infected areas. The combination has a very broad activity against mainly all gram-positive and gram-negative bacteria. After patenteral application, within 1-2 hours, therapeutic blood levels are attained, which are maintained for a period of more than 20 hours.